Autophagy😊

Autophagy

notion image
notion image
  • Definition:
    • "Self-eating" (auto = self, phagy = eating).
    • Also "self-feeding," "cell cannibalism."
  • Nobel Prize: Sir Yoshinori Ohsumi (2016).
  • Conditions:
    • Old age
    • Malnutrition
    • Linked to neurodegenerative conditions: 
      • Alzheimer's
      • Parkinson's disease.
  • Marker:
    • LC3 (Light Chain 3).
  • Most Important Gene: 
    • ATG1 (Autophagy-related gene 1).

Diseases (ATG Gene Mutations):

  • ATG 5 gene mutation:
    • Risk of tuberculosis
  • ATG 16L mutation:
    • Associated with IBD
      • (Crohn's, ulcerative colitis).