Normal Central Nervous System Cells & Variations

Normal Central Nervous System Cells & Variations

Astrocyte

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  • Shape: Star-shaped.
  • Function: Forms the blood-brain barrier.
  • Immunohistochemistry: 
    • GFAP positive 
      (Glial Fibrillary Acidic Protein)
      → appears brown.

Microglia (Brain Macrophages) & Variations

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Feature
Description
Associated Condition
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Rod cells
Elongated microglia
Neurosyphilis
Tryp (TP) on Road → People on road (Rod cells) has syphillis ()
Neuronophagia
Macrophages eating damaged neurons
Polio, Rabies
Phagia → Bite (Rabies) and eat (Polio → orofecal)
Microglial nodule
Cluster of microglia
HIV
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Globoid bodies
Globe-like groups of microglia
Krabbe's disease
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