Preventive Paediatrics😊

Preventive Paediatrics

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Child Survival Schemes

Under-Five Clinics:

  • Elements:
    • Promotive care
    • Core
    • Family planning
    • Curative care
    • Preventive care
    • Health Education
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Kangaroo mother care

  • Elements (SAANS):
    • Skin-to-skin (Hypothermia prevention)
    • Airway disease prevention
    • Ambulatory support
    • Nutritional support (Exclusive breastfeeding)
    • Support (Emotional)

Indication

  • All stable low birth weight neonates

Components

  1. Kangaroo position:
      • Skin-to-skin contact
  1. Kangaroo nutrition:
      • Exclusive breastfeeding,
      • no supplementation
  1. Early discharge from hospital

Advantages

  • Lesser chances of:
    • Sepsis,
    • Hypothermia
    • Neonatal mortality
  • Higher weight gain (better gain of anthropometric parameters)
  • Earlier discharge from hospital
  • Higher breastfeeding rates

STOP KMC

  • baby attains 2.5 Kg or 37 weeks.

GOBI FFF

  • Given by WHO/UNICEF.
  • Aim: Promote child survival
  • Components:
    • Growth monitoring
    • Oral rehydration solution
    • Breastfeeding
    • Immunization
    • Female fertility
    • Female literacy
    • Food (Female nutrition)

BFHI, MAA, CLMC:

  • Baby Friendly Hospital Initiative (BFHI):
    • UNICEF initiative to promote child survival
  • Mother’s Absolute Affection (MAA):
    • Gov of India, MoHFW initiative to promote breastfeeding
      • Normal delivery: Within 1 hour
      • C-section: Within 4 hours
  • Comprehensive Lactational Management Centers (CLMC):
    • Promote breast milk donation
    • CHCs & District hospitals:
      • Breast pumps & breastmilk storage facilities (+)

Important Dates & Weeks

Date/Period
Event
April 14th
Ayushman Bharat Health & Wellness Centre Day
Last week of April
World Immunization Week
May 28th - June 8th
Intensified Diarrhoea Control Fortnight
August 1st - 7th
World Breastfeeding Week
September 1st - 7th
National Nutrition Week
November 15th - 21st
Newborn Week

Management of Childhood Pneumonia

WHO IMNCI PROTOCOL

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  • Cough/cold:
    • No pneumonia.
    • Home care advice.
  • Fast breathing/chest indrawing:
    • Pneumonia.
    • Oral amoxicillin/home care advice.
    • Reassessed after 48 hours.
      • If the child has worsened, refer to a higher center.
  • General danger signs:
    • Severe pneumonia/very severe disease.
    • First dose antibiotic/referral for injectable antibiotic
      • 1st dose of Inj. Ampicillin and Gentamycin

SAANS PROTOCOL:

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  • Social Awareness & Action to Neutralize Pneumonia Successfully.
  • Launched in 2019 to reduce deaths due to childhood pneumonia.
  • For 2-59 months child with cough +/- difficult breathing.

Management

Condition
Signs → SAANS Protocol
Severe pneumonia/
very severe disease
General danger signs
• Convulsions
•
Lethargy
•
Inability to drink or breastfeed
•
Persistent vomiting
•
Unconsciousness
•
Stridor in a calm child

OR

Chest indrawing
Pneumonia
Fast breathing:
- < 2 months: ≥ 60 breath/min
- 2–11 months: ≥ 50 breaths/min
-
12–59 months: ≥ 40 breaths/min
No pneumonia/cough or cold
No signs of severe pneumonia or pneumonia

Severe Pneumonia

  • ASHA:
    • Pre referral dose of Oral amoxicillin + referral.
  • CHO (Community Health Officer):
    • Oral amoxicillin + IM Gentamicin + Hospitalization/Referral
Important
If SAANS protocol is mentioned → Refer
If not mentioned → WHO → Oral amox for 5 days
Important
If SAANS protocol is mentioned → Refer
If not mentioned → WHO → Oral amox for 5 days

Mission Indradhanush

2024 IMI 5.0
(INTENSIFIED MISSION INDRADANUSH)

EVin
EVin
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ANMOL
ANMOL
Kilkari
Kilkari
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Vaccine Applications
Role
ANMOL
• Track Pregnant females and children
• Use Tablet to monitor
SAFE VAC
• Adverse effect following Vaccine
EVin
↳ Electronic Vaccine Intelligence Network
• To manage Immunization logistics
• Electronic win → logistics
UWin
• Online immunisation card
•
0 - 5 year old
•
U win a card
Kilkari
• Information sent out via Mobile App
• For
Pregnant females
•
Immunization compliance
Other Portals
Service provided
eHospital
Hospital records maintenance; OPD services
e-Sanjeevani
Telemedicine services
eRakt Kosh
Blood banks
NHP
National health portal for national guidelines
mera aspatal
For OPD registration (↑Hospital services)
mDiabetes
Diabetes awareness
m-cessation
To quit smoking
NIKSHAY
TB drug compliance, register TB cases
NIKUSHT
Leprosy drug compliance

New Updates:

  1. Rotavirus vaccine:
    1. Open vial policy
  1. 3rd dose of fIPV: Newly introduced (2024)
  1. JE killed vaccine

Diseases covered: 12

  • Indra has 12 wives → 1 subnational
OPV 0 dose not counted in Primary doses
OPV 0 dose not counted in Primary doses
  • 11 Nationally:
    • DPT, Polio, MR, Severe TB, Rotavirus, HepB, Hib, PCV
  • 1 Sub-nationally:
    • JE

National Immunization Schedule

Number of doses:

  • OPV:
    • Birth dose + 3 primary + 1 booster
      • Birth dose or zero dose is not considered Primary dose
    • 2 drops of polio can save life
    • Note: Rotavirus - associated with diarrhoea - 5 drops
  • Pentavalent:
    • 3 primary + 2 boosters

Schedule:

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Age Group
Vaccines
Inj and syrups
At birth
BCG (at birth), OPV-0 dose, Hep B-birth dose
(No fever)
ã…¤
6 weeks
OPV-1, Rota-1, Pentavalent-1, fIPV-1, PCV-1
ã…¤
10 weeks
OPV-2, Rota-2, Pentavalent-2
ã…¤
14 weeks
OPV-3, Rota-3, Pentavalent-3, fIPV-2, PCV-2
ã…¤
9 months
JE-1, Measles/MR-1, Vit A, PCV booster, fIPV-3
4 injection
1 syrup
16-24 months
JE-2, Measles/MR-2, DPT 1st booster, OPV booster
ã…¤
5-6 years
DPT 2nd booster
ã…¤
10 & 16 years
Td
ã…¤
Pregnant Women
Td-1: Early in pregnancy,
Td-2: 4 weeks after Td-1
Td booster:
If pregnancy occurs within 3 years of last pregnancy and 2 Td doses were received
ã…¤
  • Fractional IPV
    • 1/5th of Full dose
  • Polysaccharide vaccine against Streptococcus pneumonia (PPSV-23)
    • Most beneficial in Sickle Cell Disease
      • (Autosplenism → ↑risk of encapsulated organisms like Strep)

Site of Vaccine Administration

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  • Mixed vaccine: Preferred
  • Vaccine type (by route):
    • Oral
    • Intradermal
    • Subcutaneous
    • Intramuscular
    • Pentavalent
  • Mnemonic:
    • MRI → Right arm
  • After 5 years, absorption from the leg decreases,
    • so the DPT 2nd booster 1s given 1n either of the upper arms

Q. You are posted at a PHC, and you have to ensure that the routine vaccination process is carried out smoothly. All of the vaccines are given at 16-24 months except:
A. DPT booster
B. OPV booster
C. Japanese encephalitis 2â„¢ dose
D. PCV booster

ANS
D. PCV booster

National Vitamin A prophylaxis program

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  • Dose:
    • 6 monthly doses
      • < 6 months: 50,000 IU
      • 6 months - 1 year or Weight < 8 kg 1,00,000 IU
      • > 1 year or > 8 kg 2 lakh IU
  • Total dose: 
    • 17 lac IU (9 megadoses)
    • Starting at 9 months
      • with measles rubella vaccine
      • One dose is given.
    • Then every 6 monthly intervals
  • Storage: 
    • Amber coloured bottle (Sensitivity to light > heat)
  • Measurement:
    • 2 mL = 2 lakh IU
    • 1 mL = 1 lakh IU

Rx for documented vit. A deficiency

  • Dose: 
    • 3 megadoses on Day 0, 1 & 14

SPECIAL FEATURES

Measles Post Exposure Prophylaxis

  • With in 3 days

Pentavalent Vaccine

  • Freeze sensitive
  • Contains: DPT + Hib + Hep B (mixed vaccine)
    • Diphtheria: Toxoid
    • Pertussis: Killed (Whole cell)
    • Tetanus: Toxoid
    • Haemophilus influenzae b (Hib): Conjugate
    • Hepatitis B: Recombinant
  • Side Effects (due to pertussis):
    • Uncontrollable cry (>3 hours)
    • Neurological deficits
    • HHE (Hypotensive hyporesponsive encephalopathy)
  • Contraindications (C/I):
    • Acellular pertusis vaccine TDaP (Safer) if
      • Progressive neurological deficits
      • Progressive developmental delays
      • Convulsions/epilepsy
    • Successive dose of DT is given for both
      • Anaphylaxis with previous dose
      • Encephalopathy for pertussis

BCG Vaccine

  • Immunization for severe TB forms
  • Route, Dose, Site: 0.1 mL, intradermal, left upper arm
  • Upper age limit: 1 year
  • C/I to 0.1 mL dose:
    • Prematurity & age <1 month
    • Very low birth weight
    • Give 0.05 mL due to skin rupture risk

Td/TT/DT

  • DPT
    • Preservative → Thiomersal
      • (preserved in thee, give to mersal)
    • Adjuvant → Aluminium hydroxide
  • Td:
    • Low dose diphtheria 2 LF units
    • (LF : Limits of Flocculation)
    • Adult dose
  • DT:
    • High dose diphtheria (>25 LF units.)
  • Serum level of tetanus antitoxin required for clinical protection
    • >0. 01 IU/ml

Tuberculin vs Insulin Syringe

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  • Tuberculin syringe has (0.1ml to 1 ml) markings
  • Insulin syringe has units 10 to 100 units
  • There is no interchangeability between the syringes

Side Effects (Vaccine)

Vaccine
Adverse Effects
BCG
• Scar, lymphadenitis
↳ Scar formation takes 8 - 12weeks
• Ulcer- M/c
• Osteitis
• Disseminated BCG
OPV
• Vaccine Associated Paralytic Polio (VAPP)
Pertussis (Pentavalent)
• Inconsolable cry (Persistent screaming > 3hrs)
• Seizures
• Hypotonic Hyporesponsive episodes
Rotavirus
• Intussusception (>6 months)
Td
• Brachial neuritis (over Deltoid)
Measles
• Measles-like rash (5-7 days post-vaccination)
• MR → Right Arm → Rash → Water
• Thrombocytopenia
•
TSS, Febrile seizure, anaphylaxis, encephalopathy
Influenza (Killed)
• GBS (Disproved now??)
Q. An eight-month-old child had a history of unusual crying and convulsion following previous vaccination after BCG, DPT and, OPV (first dose), and Hepatitis B. Now, parents have brought their children to the next dose of vaccination. Which vaccine 1s contraindicated in the situation?
A. Measles
B. DPT
C. HepatitisB
D. DT
Inconsolable crying following the DPT/ Pentavalent vaccine due to the pertussis component is not an absolute contraindication for the DPT/ Pentavalent vaccine.
Q. A 1-year-old child presented to OPD for vaccination. He had 1dose of DPT 6 weeks after birth. After that other doses were not administered. What should be the next step? (9
A. Restarts DPT
C. Give 2nd dose
B. Give only DT
D. Not to give anything
Q. You are the medical officer of a PHC. A child 1s due for measles vaccine however he 1s having diarrhea. What should be the plan of action?
A. Donot give the vaccine
B. Can give the vaccine to the child and ask the mother to wait for 2 an hour at the PHC
C. Can give the vaccine to the child and ask the mother to leave
D. Notsure
 
Q. A child with steroid dependent nephrotic syndrome been on daily oral steroids for 3 weeks. All of the following are true about the vaccination of this child except
  • A. Give all immunization according to schedule
  • B. Sibling should not be given with OPV
  • C. Give killed vaccines
  • D. Pneumococcal vaccine should ideally be given before commencing the treatment
ANS
A → avoid live vaccines in immunocompromised

Contraindications

Conditions
Contraindication
Pregnancy
All live vaccines are contraindicated, except yellow fever.

*
Yellow fever vaccine is not used in India due to storage requirements and it being an exotic disease there.
Mild to moderate Fever
All vaccines are given, except typhoid oral vaccine, for mild to moderate fever.
Diarrhea
No contraindications
High-grade fever,
acute disease
Withhold all vaccines
Asymptomatic HIV
None are contraindicated
Symptomatic HIV
All live vaccines are contraindicated
Uncontrolled? Epilepsy
DPT (Pertussis component)
Progressive neurologic disease
DPT contraindicated (pertussis component).
Epilepsy (Controlled)
DPT can be given to people with convulsions controlled by anti-epileptics.
Immuno-suppression and corticosteroids
* All live vaccines are contraindicated.
* Stop for a minimum of 2 weeks, then give the live vaccine.
Egg Allergy
Yellow fever and Influenza vaccines are contraindicated.
Neomycin allergy
Measles, MR

Neomycin in Measles to prevent TSS
Live vaccine
Pregnancy,
radiation therapy,
severe symptomatic immunodeficiency,
cancer/malignancy

Contraindicated in
Digeorge
Wiskott-Aldrich Syndrome
Ataxia telangiectasia


NOT Contraindicated in Complement deficiency
 

Viability of Vaccines & Unimmunized Child

Cold Chain

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Dial thermometer → Refrigirator temp
Dial thermometer → Refrigirator temp

Elements:

Equipment
Specifications
Temperature
+2 to +8ËšC
Day carrier
• Vials: 6 - 8
• Icepacks:
2
• For Outreach program
• Duration: 24 - 48 hrs (a day)
Vaccine carrier
• Vials: 16-20
• Icepacks:
4-6
• For Outreach program
• Duration: 24 - 48 hrs (a day)
Cold box
• Icepacks: 16-20
• Vials:
75-300
• Supply vaccine to Peripheral Centres
• Duration:
48 - 96 hrs
Ice Lined Refrigerator (ILR)
Requires >8 hours continuous electricity in 24 hours
Deep freezer
Used for making icepacks
Walk-in cold room
Long-term storage
ICEPACK
2 Holes → for keeping Vaccines
ICEPACK
2 Holes → for keeping Vaccines
Cold carrier
Cold carrier

Vaccine Sensitivity

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  • Freeze Sensitive:
    • Hep B > Pentavalent > PCV > IPV > DPT/Td
    • HPPiT
  • Heat sensitive:
    • Reconstituted BCG > OPV > MR > BCG > Rota
    • RB OMB R → Japan
  • Hep A Vaccine → Both live and killed vaccine
  • KILLED
    • K → KFD
    • I → IPV
    • LL → Lu (flu) → (Influenza)
    • E → Enceph → JE
    • D → Dogs → Rabies
  • I (Influenza) Love (Live) Chick (Chicken Pox) EMBRYO
    • E: JE
    • M: MR
    • B: BCG
    • R: Rota
    • Y: Yellow fever
    • O: OPV

Deep Freezer

  • Top Part → Most Cold
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Ice Lined Refrigerator (ILR)

  • Bottom Part → Most cold
  • Temperature Monitor by
    • Dial thermometer
    • Twice a day
    • By MO
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Classification
Pneumonic
Vaccines
Notes
Heat-Sensitive Vaccines
(Top to bottom order in ILR)
Don't Hit People In This Room Because Japanese Manners Outshine
Diluents,
Hep B,
Pentavalent, PCV, IPV,
Td, TT,
Rotavirus,
BCG,
JE,
Measles,
Rubella,
OPV
Stored at +2 to +8ËšC in ILR, listed in order of placement
Live Vaccines
Cool Boys Love CRIME Types


Most (Mumps) Beautiful (BCG) Place (Plague) in (influenza) the (typhoid) World (Mumps, yelloW fever) → ROME (Rubella, Rota, Oral Polio, Measles, jE + Varicella) C3 (chicken pox, cholera, covid)
COVID
(viral vector)/
Cholera,
BCG,
Live,
Chicken Pox,
Rubella,
Influenza,
Measles, Mumps,
JE,
Typhoid oral (Ty21)
Contain live attenuated organisms
Killed Vaccines
P3 Killed In A Cold Rabbit Jelly


RIP ACE
Plague,
Polio,
Pertussis,
Killed KFD,
Influenza,
COVID (Covaxin),
Rabies,
JE
Hep A
Contain inactivated organisms

NOTE:

  • 2 live vaccines should not be given together
  • Minimum 4 weeks gaps should be present
  • Avoid spirit wipe before Live vaccines

Vaccine Vial Monitor (VVM)

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  • Example of Appropriate technology
  • Checks heat stability
  • Discard point:
    • Inner square same color/darker than outer circle
      • Lighter than outer: Usable
      • Same/darker: Discard
  • For freeze dried/reconstituted vaccine
    • VVM on cap
  • For liquid vaccine
    • VVM on body

Open Vial Policy

  • Used up to 28 days after opening vial
  • Indicators → P-Toluene sulphate / Diacetylene
    • VVM Tola → Very very Magn Tola
  • Measures cumulative heat exposure
  • Indirectly tells about POTENCE
  • Not Efficacy/expiry

Do not follow Open Vial Policy:

  • MBJ/ Covid/ Yellow Fever
  • Mnemonic: Open cheyth vachuda → Meals, Ruby and Bee (honeybee)
  • To be used within 4 hours after dilution
ã…¤
Diluent
Used within
Wastage factor
BCG
• Freeze dried → Powder form
•
NS
• 4 hrs
• 2
Measles/Rubella
• Distilled water
• (M ⇔ W)
• 4 hrs
• 1.3
JE (live vaccine)
(Previously)
• Phosphate buffer
•
Live Photo
• Japan Potti
• 2 hrs
ã…¤
Yellow Fever
ã…¤
• 1/2 hrs
ã…¤

Conditions to be met for open vial policy

  • All aseptic techniques have been followed.
  • Vaccine vial septum has not been submerged in water.
  • Date of first time opening of vial is clearly mentioned on the label.
  • Expiry date of vaccine has not yet reached.
  • Cold chain (2 - 8 degree) has been maintained properly.

Rotavirus (under open vial):

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  • VVM on Cap → Don't follow Open Vial policy
    • Use within 4-6 hours post-dilution
  • VVM on side → OVP applicable

Shake Test

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  • For freeze sensitive vaccines:
    • DPT, Hep B, Pentavalent, PCV
    • Mnemonic: Shake but Dont (DPT) Hit (Hep B) People (Penta, PCV)
  • Method:
    • Shake vial, compare to freeze-destroyed control
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      • Clear liquid:
        • Precipitates (Aluminium hydroxide)
          • Discard vial
            • DPT
              • Preservative → Thiomersal
                • (preserved in thee, give to mersal)
              • Adjuvant → Aluminium hydroxide
      • White amorphous liquid:
        • Undamaged vial
          • Usable

Universal Immunization Program Evaluation

  • Fully Immunized Child
    • Better indicator
      • Received all due vaccines till first year of life
      • Evaluated at age: 12-23 months
  • Completely Immunized Child
    • Received all due vaccines till 2 years of age
    • Evaluated at 5 years of age

Order of giving vaccine

  1. Oral vaccine
  1. Intradermal vaccine
  1. Subcutaneous vaccine
  1. Intramuscular vaccine
  1. Pentavalent vaccine

Unimmunized Child

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Upper Age Limit to Start Vaccine

Time
Vaccine
ã…¤
Till 24 hours
Hepatitis B - birth dose
ã…¤
Till 15 days
OPV birth dose
ã…¤
Upto 1 year
* BCG
*
Rotavirus Vaccine
*
Pentavalent
* fIPV
*
PCV
* Hepatitis B vaccine alone can also be given till 1-year

Government says if started, always finish
BR PP Hep B
Upto 5 years
* OPV
* MR vaccine
* Vit A drops
5 vayssil OMA

Upto 6 years
HiB
6 yr avumbo → Hi
Upto 7 years
DPT
Deep 7
Upto 15 years
JE
15 vayassavumbo → japanil povam
Lifelong
Td
ã…¤
  • Penta can be only given till 1 year
    • After that, it is given in split as
      • Hib
      • DPT
  • Vaccine that should be given beyond 9 years of age
    • HPV.
  • Vaccines that can be given to adolescents
    • TT, Tdap, Td.
    • HepB.
    • Influenza.
    • JE and Rabies.
  • Vaccines contraindicated in egg allergy
    • When vaccines are cultured, an egg yolk medium is used.
    • Vaccines contraindicated are:
      • Influenza vaccine.
      • Yellow fever vaccine.
  • Vaccine that can cause thrombocytopenia
    • Measles vaccine.
  • Vaccine that acts faster than the incubation period of the disease it prevents
    • Varicella vaccine.
    • Measles vaccine.
Which maternal antibodies do not confer substantial immunity in a newborn?
A. Tetanus
B. Polio
C. Diptheria
D. Measles
ANS
Polio